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META Blend 120 mg

META Blend 120 mg

Original price was: $90.00.Current price is: $60.00.

In stock

Estimated delivery dates: Apr 18, 2026 - Apr 21, 2026
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Description

Technical Monograph: HRL-META | Tri-Phase Mitochondrial Composite

Product Code: HRL-META-120 | Total Active Mass: 120 mg

This advanced laboratory composite is engineered for multidimensional research into cellular bioenergetics and metabolic signaling. By combining a core coenzyme with a mitochondrial-derived peptide and a selective NNMT inhibitor, this 120 mg blend allows for the concurrent evaluation of NAD-dependent deacetylation and AMPK-mediated energy homeostasis.

Molecular Specification & Composition

Component Sequence / Chemical Type Mass Role in Research
N-AD-OX (NAD+) Coenzyme Redox Reagent 100 mg Sirtuin (SIRT1) Activation
MOT-Sc Mitochondrial-Derived Peptide 10 mg AMPK Signaling & Metabolic Flux
5-AM-1MQ Small Molecule NNMT Inhibitor 10 mg SAM-Level Regulation

Analytical Characteristics

  • Synergistic Metabolic Modeling: Formulated to study the intersection of the NAD+/Sirtuin pathway and the AMPK-mediated glucose uptake mechanism in vitro.

  • Epigenetic Signaling Design: Engineered to observe the impact of NNMT inhibition on methyl donor availability and gene expression related to cellular energy.

  • Structural Stability: Vacuum-sealed and lyophilized to maintain the redox potential of the NAD+ fraction and the sequence integrity of the MOT-Sc peptide.

Laboratory Application Fields

  1. Mitochondrial Biogenesis Research: Investigating the concurrent upregulation of PGC-1$\alpha$ and mitochondrial DNA transcription.

  2. Sirtuin-AMPK Axis Mapping: Analysis of the cross-talk between NAD-dependent deacetylases and the cellular “energy sensor” (AMPK).

  3. Methylation Pathway Studies: Evaluation of the impact of 5-Amino-1MQ on nicotinamide -methyltransferase activity and its influence on metabolic efficiency.

  4. Bioenergetic Recovery Models: Studying the restoration of ATP synthesis and redox balance in stressed cellular environments.

Storage & Handling Protocols

  • Thermal Management: Store lyophilized vials at -20°C. This composite is highly sensitive to moisture and heat due to the NAD+ component.

  • Reconstitution: Maintain at 2-8°C post-reconstitution. Use an appropriate laboratory aqueous solution; do not subject the vial to high-frequency agitation or prolonged light exposure.

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