Description
HPLC / LC-MS
THIRD-PARTY
Technical Monograph: Tirzepatide (Dual GIP & GLP-1 Receptor Co-Agonist)
Product Code: HRL-GLP-TZ | Lyophilized Polypeptide Solid
Tirzepatide is a synthetic 39-amino-acid unimolecular linear peptide engineered to act as a dual agonist at both the Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) receptors. Modified with an engineered C20 fatty diacid moiety attached via a hydrophilic linker at position 20 (Lys), Tirzepatide demonstrates calibrated dual receptor binding profiles designed for comparative incretin kinetics, beta-cell signaling cascades, and metabolic homeostatic modeling.
Core Specifications
Primary Laboratory Research Domains
- Dual Incretin Synergism: Mapping cAMP accumulation and downstream protein kinase A (PKA) pathways in cell assays co-expressing human GIPR and GLP-1R.
- Pancreatic Islet Dynamics: In vitro observation of glucose-dependent insulin secretion (GSIS) and glucagon counter-regulatory kinetics under physiological glucose gradients.
- Lipid Metabolism & Adipocyte Signaling: Investigating cellular lipid partitioning, adipogenesis markers, and lipoprotein lipase (LPL) regulation in primary adipocyte cultures.
Storage & Handling Guidelines
- Lyophilized State: Store intact vials at -20°C for optimal baseline preservation. The compound exhibits chemical stability at room temperature during standard analytical shipping.
- Reconstitution: Dissolve using laboratory-grade bacteriostatic water (0.83%–0.9% benzyl alcohol) or sterile 0.9% NaCl solution. Store reconstituted aliquots at 2°C to 8°C; do not subject to excessive mechanical agitation.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended exclusively for in vitro research, analytical validation, and preclinical laboratory characterization. It is NOT a pharmaceutical drug, cosmetic, food additive, or dietary supplement, and it is NOT intended for human or animal consumption, subcutaneous administration, therapeutic use, or clinical diagnosis.
Any use outside of a regulated scientific facility is strictly prohibited. The purchasing institution or researcher assumes full regulatory compliance, handling responsibility, and safety accountability. Hudson Research Lab does not provide clinical guidance, therapeutic dosing, or medical instructions. Keep securely stored and out of reach of children.
