Description
Technical Monograph: ADP-TID-05 | Targeted Pro-Apoptotic Reagent
Product Code: HRL-ADP-05 | Total Peptide Mass: 5 mg
This high-purity peptidomimetic is a specialized laboratory reagent engineered for research into the targeted disruption of specific vascular structures. The 5 mg variant of this pro-apoptotic sequence is optimized for investigating the selective induction of programmed cell death within the blood vessels supplying white adipose tissue (WAT) in vitro.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Peptide Type | Pro-Apoptotic Peptidomimetic |
| Sequence Strategy | Vascular Targeting Domain + Apoptotic Domain |
| Purity (HPLC) | >99.0% |
| Total Mass | 5 mg Lyophilized Powder |
Analytical Characteristics
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Dual-Domain Functionality: Formulated with a homing sequence designed to bind to Prohibitin (PHB) receptors in vascular endothelial cells, paired with a synthetic “pro-apoptotic” sequence.
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Selective Mitochondrial Disruption: Engineered to initiate the mitochondrial-mediated apoptotic pathway specifically within the target cellular models.
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Structural Stability: Vacuum-sealed to preserve the delicate peptide-bond interactions required for successful receptor-mediated endocytosis.
Laboratory Application Fields
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Vascular Targeting Research: Investigating the affinity of the homing domain for the PHB-receptor in localized cellular models.
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Adipocyte Homeostasis Modeling: Analysis of the downstream metabolic effects when the primary nutrient supply to white adipose tissue is inhibited.
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Pro-Apoptotic Signaling Studies: Evaluation of the peptide’s role in triggering Cytochrome-c release and caspase-activation within endothelial cells.
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Metabolic Pathway Mapping: Studying the impact of targeted vascular clearance on systemic energy expenditure simulations.
Storage & Handling Protocols
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Thermal Management: Store lyophilized vials at -20°C for maximum molecular integrity.
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Reconstitution: Maintain at 2-8°C post-reconstitution. This complex sequence is highly sensitive to mechanical stress; avoid high-velocity agitation and protect from all UV exposure.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
