Description
Technical Monograph: S-MX-05 | Synthetic ACTH Fragment Analog
Product Code: HRL-SMX-05 | Total Peptide Mass: 5 mg
This high-purity synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) is a stabilized analog of the ACTH (4-10) fragment. Engineered for advanced neurobiological research, this 5 mg variant is optimized for investigating the upregulation of neurotrophic factors and the modulation of the melanocortin system in neural cellular models.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Sequence Fragment | L-Methionyl-L-Glutamyl-L-Histidyl-L-Phenylalanyl-L-Prolyl-Glycyl-L-Proline |
| Molecular Weight | 813.9 g/mol |
| Purity (HPLC) | >99.0% |
| Total Mass | 5 mg Lyophilized Powder |
Analytical Characteristics
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Neurotrophic Induction Research: Formulated to study the rapid induction of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) mRNA expression in vitro.
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Melanocortin Receptor Affinity: Specifically designed to investigate the non-hormonal signaling pathways of the MC4 and MC5 receptors within the central nervous system.
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Enhanced Metabolic Stability: The C-terminal Pro-Gly-Pro sequence is engineered to provide superior resistance to aminopeptidases, ensuring high-fidelity data collection in various research media.
Laboratory Application Fields
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Neurogenesis Modeling: Investigating the proliferation and survival of neural progenitor cells in hippocampal models.
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Synaptic Plasticity Research: Analysis of the peptide’s influence on long-term potentiation (LTP) and neurotransmitter turnover (dopamine and serotonin).
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Ischemic Stress Modeling: Studying the impact of ACTH-analogs on cellular survival during oxygen-glucose deprivation (OGD) simulations.
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Enzymatic Activity Studies: Evaluation of the peptide’s influence on acetylcholinesterase activity and cholinergic signaling.
Storage & Handling Protocols
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Thermal Management: Store lyophilized vials at -20°C for maximum molecular integrity.
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Reconstitution: Maintain at 2-8°C post-reconstitution. This heptapeptide is highly sensitive to thermal stress; ensure the solution is kept refrigerated and protected from UV light during baseline testing.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
