Description
Product Name: DSIP (Delta Sleep-Inducing Peptide) Molecular Formula: C35H48N10O15 Molar Mass: ~848.81 g/mol Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Product Overview DSIP was first discovered in 1974 by the Swiss Schoenenberger-Monnier group. It is a unique amphiphilic peptide that can cross the blood-brain barrier (BBB) freely—a rare trait for neuropeptides. Unlike sedatives that force sleep through widespread CNS depression, DSIP acts as a modulator. It does not simply “cause” sleep but rather facilitates the brain’s natural ability to enter the deep, restorative stages of sleep (Delta rhythm), particularly under conditions of stress or circadian disruption.
Mechanism of Action The precise mechanism of DSIP is complex and involves multiple systems rather than a single receptor site:
-
Sleep Regulation: It influences the activity of the reticular activating system (RAS), promoting the onset of slow-wave sleep (SWS) and increasing the production of endogenous sleep factors.
-
Stress Modulation: DSIP significantly reduces the release of ACTH (Adrenocorticotropic hormone) and cortisol, effectively dampening the physiological stress response.
-
Antioxidant Activity: Research indicates it may inhibit lipid peroxidation in brain tissue, offering neuroprotective effects against oxidative stress.
-
Endocrine Normalization: It has been observed to normalize the secretion of LH (Luteinizing Hormone) and growth hormone in models where these rhythms have been disrupted.
Research Applications DSIP is utilized in a variety of neurophysiological and endocrine studies, including:
-
Insomnia and Narcolepsy: Investigating the normalization of circadian rhythms and sleep architecture in animal models.
-
Pain Management: Studies suggesting DSIP may potentiate the analgesic effects of endogenous opioids and reduce pain perception.
-
Withdrawal and Addiction: Research into its ability to mitigate withdrawal symptoms from opiates and alcohol by stabilizing neurotransmitter levels.
-
Gerontology: Exploring its potential to restore sleep patterns and hormonal balance in aging models.
Storage and Handling
-
Storage: Store lyophilized powder at 2-8°C. Protect from light.
-
Stability: Stable for 2 years when stored properly in lyophilized form. Reconstituted solution is stable at 4°C for approximately 3–4 weeks.
Disclaimer: This material is sold for research and development purposes only. It is not intended for human ingestion, diagnostic, therapeutic, or clinical procedures. All research must be conducted by qualified professionals in a laboratory setting.
