Description
Overview
MOTS-C is a mitochondrial-derived peptide that plays a key role in regulating cellular metabolism and energy homeostasis. It is a 16-amino-acid peptide encoded within mitochondrial DNA and is being studied for its potential
Product Name: MOTS-c Molecular Formula: C101H152N28O22S2 Molar Mass: ~2174.6 g/mol Sequence: Met-Arg-Trp-Qln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Product Overview MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) represents a paradigm shift in peptide research, as it originates from the mitochondrial DNA. It acts as an endocrine signal, often described as a “mitokine,” that communicates mitochondrial status to the rest of the organism. This signaling capability allows it to profoundly influence systemic metabolism, particularly in skeletal muscle and adipose tissue.
Mechanism of Action MOTS-c functions primarily by targeting the folate cycle and the AMPK pathway:
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Folate Cycle Inhibition: It inhibits the folate cycle at the level of 5AICAR ribonucleotide, increasing cellular levels of AICAR.
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AMPK Activation: The increase in AICAR activates Adenosine Monophosphate-activated Protein Kinase (AMPK), the cell’s master metabolic switch. This mimics the cellular response to caloric restriction and endurance exercise.
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Glucose Uptake: By activating AMPK, MOTS-c promotes the translocation of GLUT4 transporters to the cell membrane, enhancing glucose uptake in muscle cells even in the absence of insulin.
Research Applications MOTS-c is a high-interest compound in the fields of gerontology and metabolic disease, utilized to study:
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Metabolic Flexibility: Enhancing the body’s ability to switch between fuel sources (carbohydrates vs. fats).
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Insulin Resistance: Counteracting insulin resistance and hyperglycemia in models of Type 2 Diabetes.
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Obesity: Preventing weight gain and reducing visceral fat accumulation in mice fed a high-fat diet.
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Longevity: Investigating the peptide’s role in extending healthspan and delaying age-related physical decline.
Storage and Handling
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Storage: Store lyophilized powder at 2–8°C (Refrigerated). Protect from light.
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Stability: Stable for 2 years when stored properly at 2–8°C. Once reconstituted, the solution should be kept at 4°C and is best used immediately or within a very short timeframe due to potential oxidation.
Disclaimer: This material is sold for research and development purposes only. It is not intended for human ingestion, diagnostic, therapeutic, or clinical procedures. All research must be conducted by qualified professionals in a laboratory setting.
