Description
Technical Monograph: P-T14-10 | Synthetic Melanocortin Agonist
Product Code: HRL-PT-10 | Total Peptide Mass: 10 mg
This high-purity synthetic cyclic heptapeptide (Ac-Nle-asp-His-D-Phe-Arg-Trp-Lys-OH) is a derivative of Melanotan II. Engineered for advanced neurobiological research, this 10 mg variant is optimized for investigating the activation of the central nervous system’s melanocortin receptors, specifically targeting the MC3 and MC4 isoforms.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Sequence Fragment | Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys-OH) |
| Structure | Cyclic Heptapeptide |
| Molecular Weight | 1025.2 g/mol |
| Purity (HPLC) | >99.0% |
| Total Mass | 10 mg Lyophilized Powder |
Analytical Characteristics
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Central Receptor Agonism: Specifically formulated to bypass peripheral vascular mechanisms, focusing on the activation of neuronal pathways in the hypothalamus.
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Cyclic Architecture: The peptide is engineered with a lactam bridge, providing superior structural stability and resistance to enzymatic degradation compared to linear analogs.
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Non-Vascular Signaling: Designed to investigate the “central” trigger of physiological responses, allowing for research into the decoupling of hormonal and vascular signaling.
Laboratory Application Fields
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Melanocortin Signaling Research: Investigating the role of the MC4 receptor in the regulation of sexual motivation and autonomic responses in vitro.
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Neuromodulatory Pathway Mapping: Analysis of the peptide’s influence on the dopamine-melanocortin interaction within the medial preoptic area (MPOA).
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Endocrine Feedback Studies: Evaluation of the peptide’s impact on the hypothalamic-pituitary-adrenal (HPA) axis under varied stimulation models.
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Energy Homeostasis Modeling: Studying the secondary effects of MC3/MC4 activation on metabolic rate and food intake simulations.
Storage & Handling Protocols
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Thermal Management: Store lyophilized vials at -20°C for maximum molecular integrity.
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Reconstitution: Maintain at 2-8°C post-reconstitution. Use sterile 0.9% NaCl or bacteriostatic laboratory water.
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Stability: This cyclic sequence is highly robust; however, it should be protected from direct UV exposure to prevent photodegradation of the Tryptophan and Phenylalanine residues.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
