Description
Product Name: 5-Amino-1MQ (5-amino-1-methylquinolinium) Molecular Formula: C10H11N2+ Molar Mass:~159.21 g/mol Solubility: Soluble in water, DMSO
Product Overview 5-Amino-1MQ is a targeted small-molecule compound that acts as a selective inhibitor of the cytosolic enzyme Nicotinamide N-methyltransferase (NNMT). While often categorized alongside research peptides due to its metabolic applications, 5-Amino-1MQ is a distinct chemical entity designed to prevent the methylation of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA).
Mechanism of Action The primary research interest in 5-Amino-1MQ stems from its ability to block NNMT activity. High expression of NNMT is often correlated with compromised metabolic function. By inhibiting this enzyme, 5-Amino-1MQ prevents the “sink” of methyl groups and nicotinamide, leading to two key biochemical outcomes in research models:
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Increased NAD+ Concentrations: By sparing nicotinamide, the compound promotes the salvage pathway, increasing intracellular NAD+ levels, a critical coenzyme for mitochondrial function and energy metabolism.
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Epigenetic Modulation: The inhibition preserves S-adenosylmethionine (SAM), the universal methyl donor, potentially influencing gene expression related to metabolic homeostasis.
Research Applications 5-Amino-1MQ is currently utilized in studies focusing on:
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Obesity and Lipid Metabolism: Investigating the reduction of white adipose tissue mass and the reversal of diet-induced obesity in murine models.
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Skeletal Muscle Physiology: Studying the proliferation of muscle satellite cells and the compound’s potential to counteract muscle wasting (sarcopenia) or enhance recovery.
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Metabolic Syndrome: Exploring the downstream effects of elevated cellular NAD+ on insulin sensitivity and oxidative stress.
Storage and Handling
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Storage: Store at 2-8°C. Protect from light.
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Stability: Stable for 2 years when stored properly in lyophilized powder form.
Disclaimer: This material is sold for research and development purposes only. It is not intended for human ingestion, diagnostic, therapeutic, or clinical procedures. All research must be conducted by qualified professionals in a laboratory setting
