Description
Technical Monograph: C-J12-ND | Short-Acting GHRH Agonist
Product Code: HRL-CJC-10 | Total Peptide Mass: 10 mg
This high-purity synthetic 29-amino acid peptide is a modified analog of the endogenous Growth Hormone Releasing Hormone (GHRH). Engineered for advanced endocrine research, this 10 mg variant is optimized for investigating the acute, pulsatile secretion of growth hormone without the extended plasma half-life associated with albumin-binding complexes.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Sequence Base | GHRH (1-29) Fragment |
| Modification | Tetrasubstituted (D-Ala2, Gln8, Ala15, Leu27) |
| Molecular Weight | 3367.9 g/mol |
| Purity (HPLC) | >99.0% |
| Total Mass | 10 mg Lyophilized Powder |
Analytical Characteristics
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Pulsatile Signaling Utility: Specifically designed to mimic the natural physiological pulses of GHRH, allowing researchers to observe discrete peaks in somatotropic activity in vitro.
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DPP-IV Resistance: The tetrasubstitution of key amino acids (replacing unstable positions with D-Ala, Gln, Ala, and Leu) is engineered to prevent rapid enzymatic cleavage while maintaining high receptor affinity.
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Rapid Clearance Profile: Unlike DAC-modified analogs, this version is studied for its short duration of action, providing a high-resolution model for acute pituitary response testing.
Laboratory Application Fields
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Somatotropic Pulse Modeling: Investigating the amplitude and frequency of pituitary hormone release when subjected to synthetic secretagogue stimuli.
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GHRH-R Agonism Research: Analysis of the binding kinetics and downstream cAMP signaling pathways of the growth hormone-releasing hormone receptor.
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Synergistic Signaling Studies: Evaluation of the “dual-pathway” approach when paired with GHS-R agonists (like GHRP-2 or GHRP-6) to observe amplified somatotropic response.
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Enzymatic Stability Testing: Studying the impact of specific amino acid substitutions on peptide longevity in varied biological research media.
Storage & Handling Protocols
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Thermal Management: Store lyophilized vials at -20°C for maximum molecular integrity.
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Reconstitution: Maintain at 2-8°C post-reconstitution. Use sterile 0.9% NaCl or bacteriostatic laboratory water.
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Handling: This 29-amino acid sequence is sensitive to mechanical stress; rotate the vial gently for dissolution and avoid high-frequency agitation.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
