Description
Technical Monograph: 5-AM-1MQ | Selective NNMT Inhibitor
Product Code: HRL-AMQ-05 / HRL-AMQ-50 | Total Mass: 5 mg / 50 mg
This high-purity small molecule (5-amino-1-methylquinolinium) is a potent, selective, and membrane-permeable inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). Engineered for advanced metabolic research, this variant is optimized for investigating the modulation of energy expenditure and the preservation of cellular methylation potential.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Chemical Name | 5-amino-1-methylquinolinium iodide/salt |
| Molecular Formula | $C_{10}H_{11}N_2^+$ |
| Molecular Weight | 159.21 g/mol (cation) |
| Purity (HPLC) | >99.0% |
| Available Mass | 5 mg or 50 mg Lyophilized Powder |
Analytical Characteristics
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Selective Enzyme Inhibition: Specifically formulated to block NNMT activity, thereby increasing the availability of -adenosylmethionine (SAM) and reducing the production of 1-methylnicotinamide (1-MNA).
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Metabolic Flux Modeling: Designed to investigate the “metabolic switch” that occurs when NNMT is inhibited, leading to the upregulation of GLUT4 and the activation of sirtuin signaling.
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Non-Peptidic Stability: As a small molecule, 5-Amino-1MQ offers high structural stability and resistance to enzymatic degradation in varied laboratory research media.
Laboratory Application Fields
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Energy Homeostasis Research: Investigating the impact of NNMT inhibition on intracellular ATP levels and the basal metabolic rate of adipocytes in vitro.
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Skeletal Muscle Modeling: Analysis of the compound’s influence on myoblast proliferation and the prevention of muscle fiber atrophy in cellular stress models.
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Methylation Pathway Studies: Evaluation of the impact on the SAM:SAH ratio and subsequent epigenetic modifications.
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Sirtuin Signaling Analysis: Studying the indirect activation of SIRT1 resulting from the increased availability of NAD+ precursors.
Storage & Handling Protocols
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Thermal Management: Store lyophilized powder at -20°C for maximum molecular integrity.
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Reconstitution: Soluble in DMSO or sterile laboratory water depending on the research model. Once in solution, maintain at 2-8°C and protect from direct UV exposure.
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Stability: This small molecule is significantly more robust than linear peptides but should still be handled under sterile conditions to prevent contamination.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
