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CJC-1295 with DAC 5 mg

CJC-1295 with DAC 5 mg

Original price was: $60.00.Current price is: $40.00.

CJC-1295 with DAC 5 mg
Synthetic research peptide in lyophilized form. Modified with DAC for extended half-life. For laboratory use only.

In stock

Estimated delivery dates: Mar 4, 2026 - Mar 7, 2026
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Description

Product Name: CJC-1295 with DAC (DAC:GRF) Molecular Formula: C165H269N47O46 Molar Mass: ~3647.28 g/mol Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Maleimidopropionic acid)-NH2

Product Overview CJC-1295 with DAC is a tetrasubstituted, 30-amino acid peptide hormone. It functions as a long-acting Growth Hormone Secretagogue (GHS). The defining feature of this compound is the addition of the Drug Affinity Complex (DAC) at the lysine residue. This reactive chemical group binds covalently to circulating serum albumin (bioconjugation) after administration, creating a depot effect that allows the peptide to remain active in the system for an extended duration compared to modified GRF 1-29 (CJC-1295 No DAC).

Mechanism of Action CJC-1295 with DAC operates by selectively binding to the GHRH receptor in the anterior pituitary gland:

  1. Albumin Bioconjugation: Upon introduction to the research subject, the DAC moiety bonds with plasma albumin. This large complex prevents filtration by the kidneys and degradation by DPP-4 enzymes.

  2. Sustained Stimulation: The albumin-bound peptide continuously stimulates somatotrophs to release growth hormone. Research indicates this results in elevated basal GH levels and preserved pulsatility.

  3. IGF-1 Elevation: The sustained GH release triggers the liver to produce higher constitutive levels of IGF-1, which mediates many of the anabolic and metabolic effects observed in studies.

Research Applications CJC-1295 with DAC is a standard in endocrinology research, used to investigate:

  • Hypertrophy: Mechanisms of muscle protein synthesis and nitrogen retention.

  • Lipolysis: The role of sustained GH elevation in fatty acid mobilization and adipose tissue reduction.

  • Pharmacokinetics: Studying half-life extension technologies for peptide therapeutics.

  • Sleep Physiology: Analyzing the relationship between GHRH stimulation and slow-wave sleep patterns.

Storage and Handling

  • Storage: Store lyophilized powder at 2-8°C. Protect from light.

  • Stability: Stable for 2 years when stored properly in lyophilized form. Once reconstituted, it should be stored at 4°C and used within a reasonable timeframe, though it is generally more stable than non-DAC variants.

Disclaimer: This material is sold for research and development purposes only. It is not intended for human ingestion, diagnostic, therapeutic, or clinical procedures. All research must be conducted by qualified professionals in a laboratory setting.

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