Description
Product Name: Modified GRF 1-29 (Tetrasubstituted GRF 1-29) Synonyms: CJC-1295 No DAC, Mod GRF 1-29Molecular Formula: C152H252N44O42 Molar Mass: ~3367.9 g/mol Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Di-Ile-Leu-Ser-Arg-NH2
Product Overview Modified GRF 1-29 is a 29-amino acid peptide hormone derived from the first 29 amino acids of endogenous GHRH. It is “tetrasubstituted,” meaning four amino acids in its sequence have been swapped to protect it from rapid cleavage by the enzyme DPP-4. While the “With DAC” version is designed for a days-long duration, Modified GRF 1-29 is designed for rapid onset and clearance, creating a sharp spike in Growth Hormone (GH) levels that mirrors physiological pulses.
Mechanism of Action Modified GRF 1-29 acts as a selective agonist for the GHRH receptor:
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Pulsatile Release: Upon administration, it binds to GHRH receptors on pituitary somatotrophs, triggering a specific, timed release of growth hormone.
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Short Duration: Because it lacks the Drug Affinity Complex (DAC), it is metabolized quickly (half-life ~30 minutes). This prevents the “GH bleed” (continuous elevation) seen with long-acting analogs, allowing the pituitary gland to reset between pulses.
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Synergy: It is most frequently researched in combination with Growth Hormone Releasing Peptides (GHRPs) like Ipamorelin or GHRP-6. The GHRP creates the “pulse” (opening the somatotrophs), while Mod GRF 1-29 amplifies the magnitude of that pulse.
Research Applications Modified GRF 1-29 is the standard GHRH analog for studies focusing on:
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Natural GH Pulsatility: Investigating the benefits of episodic GH secretion versus continuous infusion.
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Anabolic Signaling: Measuring acute increases in IGF-1 and protein synthesis following pulsatile administration.
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Fat Metabolism: Studying the lipolytic effects of GH pulses in adipose tissue.
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Sleep Architecture: Researching the impact of timing GHRH administration on slow-wave sleep cycles.
Storage and Handling
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Storage: Store lyophilized powder at 2-8°C. Protect from light.
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Stability: Stable for 2 years in lyophilized form. Once reconstituted, it is relatively fragile; store at 4°C and use within 2–3 weeks.
Disclaimer: This material is sold for research and development purposes only. It is not intended for human ingestion, diagnostic, therapeutic, or clinical procedures. All research must be conducted by qualified professionals in a laboratory setting.
