Description
Technical Monograph: I-PAM-10 | Selective GHS-R Agonist
Product Code: HRL-IPA-10 | Total Peptide Mass: 10 mg
This high-purity synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) is a potent and highly selective agonist of the Growth Hormone Secretagogue Receptor (GHS-R1a). Engineered for advanced endocrine research, this 10 mg variant is optimized for investigating the pulsatile secretion of growth hormone without the concurrent induction of cortisol or prolactin release in vitro.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Sequence Fragment | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| Peptide Type | Pentapeptide (5-Amino Acid) |
| Molecular Weight | 711.9 g/mol |
| Purity (HPLC) | >99.0% |
| Total Mass | 10 mg Lyophilized Powder |
Analytical Characteristics
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High Receptor Selectivity: Specifically formulated to bind the GHS-R1a receptor with high affinity, allowing for high-resolution data collection on somatotroph activation while remaining neutral toward the ACTH and Prolactin pathways.
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Non-Ghrelin Mimetic Side Effects: Designed to study the stimulation of the somatotropic axis without the significant increase in hunger-signaling (orexigenic effect) typically associated with less selective agonists.
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Structural Stability: The inclusion of D-amino acids (D-2-Nal, D-Phe) and 2-aminoisobutyric acid (Aib) is engineered to prevent rapid enzymatic cleavage, ensuring a stable observation window in cellular research media.
Laboratory Application Fields
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Somatotropic Axis Research: Investigating the kinetics of pulsatile growth hormone release in pituitary cell culture models.
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GHS-R1a Mapping: Analysis of the binding affinity and secondary messenger cascades (PLC/IP3) triggered by synthetic secretagogues.
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Metabolic Pathway Studies: Evaluation of the peptide’s influence on nitrogen retention and protein synthesis markers in specialized cellular models.
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Gastrointestinal Motility Modeling: Studying the secondary interaction of ghrelin agonists with gastric emptying rates in isolated tissue simulations.
Storage & Handling Protocols
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Thermal Management: Store lyophilized vials at -20°C for maximum molecular integrity.
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Reconstitution: Maintain at 2-8°C post-reconstitution. Use sterile 0.9% NaCl or bacteriostatic laboratory water.
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Handling: This pentapeptide is relatively robust due to its D-isomer components but should still be protected from high-frequency agitation and direct UV exposure to prevent degradation of the Histidine residue.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
