Description
Technical Monograph: C-J12-DAC | Extended-Release GHRH Agonist
Product Code: HRL-CJC-DAC-05 | Total Peptide Mass: 5 mg
This high-purity synthetic 30-amino acid peptide is an analog of Growth Hormone Releasing Hormone (GHRH). Engineered for advanced endocrine research, this 5 mg variant includes a Drug Affinity Complex (DAC)—a maleimido-derivative of the lysine residue—optimized for investigating prolonged somatotropic signaling through covalent albumin binding.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Sequence Base | GHRH (1-29) |
| Modification | Tetrasubstituted + Drug Affinity Complex (DAC) |
| Molecular Weight | 3647.2 g/mol |
| Purity (HPLC) | >99.0% |
| Total Mass | 5 mg Lyophilized Powder |
Analytical Characteristics
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Albumin-Binding Technology: Specifically formulated with a DAC moiety to facilitate spontaneous covalent bonding with endogenous albumin, allowing for a half-life measured in days rather than minutes.
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Resistance to DPP-IV: The tetrasubstitution (D-Ala, Gln, Ala, and Leu) is engineered to prevent enzymatic cleavage, ensuring sustained activation of the GHRH receptor in vitro.
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Pulsatile Secretion Modeling: Designed to investigate the “bleeding” effect of growth hormone secretion when subjected to a constant, long-acting secretagogue stimulus.
Laboratory Application Fields
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Somatotropic Axis Research: Investigating the long-term impact of sustained GHRH agonism on pituitary receptor sensitivity.
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Plasma Half-Life Modeling: Analysis of the covalent binding kinetics between modified peptides and albumin in various research media.
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Endocrine Feedback Studies: Evaluation of the peptide’s influence on the IGF-1 feedback loop in isolated biological systems.
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Metabolic Pathway Mapping: Studying the impact of continuous GH stimulation on lipid metabolism and nitrogen retention in cellular models.
Storage & Handling Protocols
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Thermal Management: Store lyophilized vials at -20°C for maximum molecular integrity.
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Reconstitution: Maintain at 2-8°C post-reconstitution. Due to the DAC modification, this peptide is highly stable, but should still be protected from extreme pH environments and direct light.
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Handling: Avoid repeated freeze-thaw cycles once in solution to maintain the integrity of the DAC moiety.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
