Description
Technical Monograph: G-HCG-5000 | Glycoprotein Gonadotropin Reagent
Product Code: HRL-HCG-5000 | Total Activity: 5000 International Units (IU)
This high-purity heterodimeric glycoprotein is a specialized laboratory reagent produced via recombinant DNA technology or extraction. Engineered for advanced endocrine research, this 5000 IU variant is optimized for investigating the activation of the LH/hCG receptor (LHCGR) and the subsequent induction of intracellular secondary messengers.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Structure | Heterodimer (Alpha & Beta Subunits) |
| Molecular Weight | ~36.7 kDa |
| Purity (HPLC/Bioassay) | >99.0% |
| Total Potency | 5000 IU Lyophilized Powder |
Analytical Characteristics
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LHCGR Agonism: Specifically formulated to mimic the action of Luteinizing Hormone (LH), triggering the downstream activation of adenylate cyclase in vitro.
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Steroidogenic Flux Modeling: Designed to investigate the rate-limiting steps of cholesterol conversion into steroid precursors within specialized cellular models (e.g., Leydig or Granulosa cell lines).
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Glycosylation Fidelity: Engineered to maintain the carbohydrate side chains essential for receptor binding affinity and biological half-life during baseline testing.
Laboratory Application Fields
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HPTA Feedback Research: Investigating the modulation of the hypothalamic-pituitary-gonadal axis and the sensitivity of negative feedback loops.
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Steroidogenesis Signaling: Analysis of the peptide’s influence on StAR protein expression and cytochrome P450 enzymatic activity.
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Receptor Downregulation Studies: Studying the impact of high-potency gonadotropin exposure on LHCGR density and cellular desensitization.
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Cellular Differentiation Models: Evaluation of the glycoprotein’s role in the maturation and differentiation of primary endocrine cell cultures.
Storage & Handling Protocols
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Thermal Management: Store lyophilized vials at -20°C. This complex glycoprotein is highly sensitive to thermal degradation.
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Reconstitution: Maintain at 2-8°C post-reconstitution. Use sterile 0.9% NaCl or bacteriostatic laboratory water. Do not shake; gentle rotation is required to maintain the tertiary structure of the protein.
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Stability: Once in solution, the bioactivity of HCG diminishes rapidly if exposed to temperatures above 8°C.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
