Description
Technical Monograph: MAT-KINE-10 | Palmitoylated Signaling Reagent
Product Code: HRL-MAT-10 | Total Peptide Mass: 10 mg
This high-purity synthetic lipopeptide is a palmitoylated pentapeptide (Pal-Lys-Thr-Thr-Lys-Ser). Engineered for advanced dermal and cellular biology research, this 10 mg variant is optimized for investigating the upregulation of structural proteins and the modulation of the extracellular matrix (ECM) through specific matrikine signaling pathways.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Sequence Fragment | Palmitoyl-Lys-Thr-Thr-Lys-Ser |
| Molecular Weight | 802.1 g/mol |
| Purity (HPLC) | >99.0% |
| Total Mass | 10 mg Lyophilized Powder |
Analytical Characteristics
-
Enhanced Lipophilicity: The palmitoyl moiety is specifically engineered to increase the peptide’s affinity for lipid bilayers, facilitating high-resolution data collection in trans-membrane signaling models.
-
Matrikine Mimetic Research: Formulated to study the “feedback loop” that triggers the synthesis of Collagen I, III, and IV, as well as fibronectin and hyaluronic acid in vitro.
-
Fibroblast Activation Utility: Designed to investigate the stimulation of dermal fibroblasts without the inflammatory markers associated with more aggressive chemical stimuli.
Laboratory Application Fields
-
Extracellular Matrix (ECM) Modeling: Investigating the concurrent upregulation of structural proteins and glycosaminoglycans.
-
Fibroblast Proliferation Research: Analysis of the peptide’s influence on the growth and metabolic activity of connective tissue cells.
-
Dermal Signaling Studies: Evaluation of the interaction between palmitoylated peptides and the deeper layers of the dermal-epidermal junction (DEJ).
-
Structural Protein Mapping: Studying the impact of matrikines on the organization and density of the fiber network in 3D tissue models.
Storage & Handling Protocols
-
Thermal Management: Store lyophilized vials at -20°C for maximum molecular integrity.
-
Reconstitution: Maintain at 2-8°C post-reconstitution. Due to its lipophilic nature, ensure complete dissolution in an appropriate laboratory carrier before application in aqueous models.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
