Description
Technical Monograph: K-PEP-10 | Hypothalamic Signaling Reagent
Product Code: HRL-KISS-10 | Total Peptide Mass: 10 mg
This high-purity decapeptide is a potent endogenous ligand for the G protein-coupled receptor GPR54 (Kiss1R). Engineered for endocrine research, this 10 mg variant is optimized for investigating the initiation of the gonadotropic signaling cascade and the regulation of the hypothalamic-pituitary-gonadal (HPG) axis.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Sequence Fragment | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Molecular Weight | 1302.5 g/mol |
| Purity (HPLC) | >99.0% |
| Total Mass | 10 mg Lyophilized Powder |
Analytical Characteristics
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GPR54 Receptor Affinity: Specifically designed to trigger the secretion of gonadotropin-releasing hormone (GnRH) in cellular models.
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Upstream Axis Modulation: Formulated to study the “master switch” of reproductive endocrinology without the feedback inhibition seen in downstream compounds.
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Structural Stability: Amidated C-terminus ensures maximum resistance to enzymatic degradation during baseline testing.
Laboratory Application Fields
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HPG Axis Regulation Research: Investigating the pulse frequency of GnRH and subsequent LH/FSH signaling pathways.
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Pubertal Initiation Modeling: Analysis of the metabolic and environmental triggers that activate the Kiss1R receptor.
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Neuroendocrine Signaling: Studying the interaction between metabolic signals (like leptin) and reproductive axis activation.
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Hormonal Homeostasis Studies: Evaluation of the peptide’s role in restoring baseline signaling in suppressed endocrine models.
Storage & Handling Protocols
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Thermal Management: Store lyophilized vials at -20°C for long-term molecular stability.
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Reconstitution: Maintain at 2-8°C post-reconstitution. This sequence is sensitive; avoid high-velocity agitation or exposure to UV light.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
