Description
Technical Monograph: M-TAN-II | Melanocortin Receptor Agonist
Product Code: HRL-MT2-10 | Total Peptide Mass: 10 mg
This high-purity cyclic heptapeptide is a non-selective agonist of the melanocortin receptors (MC1, MC3, MC4, and MC5). Engineered for photobiological and endocrine research, this 10 mg variant is optimized for investigating the upregulation of eumelanin synthesis and the modulation of central metabolic signaling pathways.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Sequence Fragment | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| Molecular Weight | 1024.2 g/mol |
| Purity (HPLC) | >99.0% |
| Total Mass | 10 mg Lyophilized Powder |
Analytical Characteristics
-
High-Affinity Receptor Binding: Engineered to bypass the rate-limiting steps of natural alpha-MSH, providing a high-resolution model for MC1R-mediated pigmentation studies.
-
Central Signaling Utility: Formulated to study the activation of the MC4R pathway in the hypothalamus, allowing for data collection on energy homeostasis and glycemic control.
-
Cyclic Structural Stability: The lactam bridge architecture ensures superior resistance to proteolytic cleavage compared to linear analogs, maintaining molecular integrity during baseline testing.
Laboratory Application Fields
-
Photobiological Research: Investigating the protective mechanisms of eumelanin against UV-induced DNA damage in dermal models.
-
Metabolic Pathway Mapping: Analysis of the melanocortin system’s influence on appetite regulation and lipid mobilization.
-
Endocrine Feedback Studies: Evaluating the cross-talk between the HPA axis and peripheral melanocortin receptors.
-
Erectile Signaling Models: Studying the neurogenic pathways involved in MC4R-mediated responses in isolated biological systems.
Storage & Handling Protocols
-
Thermal Management: Store lyophilized vials at -20°C for maximum molecular integrity.
-
Reconstitution: Maintain at 2-8°C post-reconstitution. Protect the reconstituted solution from direct light exposure to prevent photodegradation of the peptide bonds.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
