Description
Technical Monograph: A-ICR-50 | Selective AMPK Activator
Product Code: HRL-AIC-50 | Total Mass: 50 mg
This high-purity cell-permeable nucleoside is a potent analog of adenosine monophosphate (AMP). Engineered for advanced metabolic research, this 50 mg variant is optimized for investigating the activation of the AMP-activated protein kinase (AMPK) pathway, which serves as a master regulator of cellular energy homeostasis.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Chemical Name | 5-Aminoimidazole-4-carboxamide ribonucleotide |
| Molecular Formula | $C_9H_{15}N_4O_8P$ |
| Molecular Weight | 338.2 g/mol |
| Purity (HPLC) | >99.0% |
| Total Mass | 50 mg Lyophilized Powder |
Analytical Characteristics
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Metabolic Signaling Activation: Specifically formulated to mimic the effect of a high AMP:ATP ratio, triggering the cellular “energy sensor” (AMPK) without physical exertion in vitro.
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Non-Hormonal Pathway Modeling: Designed to bypass the androgenic and growth hormone axes, providing a clean model for studying glucose uptake and lipid oxidation.
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Structural Stability: Vacuum-sealed to preserve the phosphate group integrity, ensuring high-fidelity activation of the ZMP-intermediate pathway.
Laboratory Application Fields
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AMPK Pathway Research: Investigating the downstream signaling of AMPK, including the inhibition of mTOR and the activation of PGC-1$\alpha$.
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Glucose Transport Modeling: Analysis of the peptide’s influence on GLUT4 translocation and insulin-independent glucose uptake.
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Lipid Oxidation Studies: Evaluation of the peptide’s role in fatty acid metabolism and the suppression of acetyl-CoA carboxylase (ACC).
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Cardiovascular Bioenergetics: Studying the impact of AMPK activation on ischemic-reperfusion injury and myocardial energy metabolism.
Storage & Handling Protocols
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Thermal Management: Store lyophilized vials at -20°C for maximum molecular integrity.
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Reconstitution: Maintain at 2-8°C post-reconstitution. This compound is stable; however, it should be protected from high-velocity agitation and extreme pH fluctuations during baseline testing.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
