KPV 10 mg

Description

Technical Monograph: K-PV-10 | Immunomodulatory Signaling Reagent

Product Code: HRL-KPV-10 | Total Peptide Mass: 10 mg

This high-purity tripeptide (Lys-Pro-Val) is a C-terminal fragment of the alpha-melanocyte-stimulating hormone ($\alpha$-MSH). Engineered for advanced cellular research, this 10 mg variant is optimized for investigating the down-regulation of pro-inflammatory cytokines and the modulation of the NF-κB transcription factor without the pigmentary effects of larger melanocortin analogs.

Molecular Specification & Composition

Analytical Characteristics

• Non-Receptor Mediated Signaling: Unlike larger peptides, KPV is studied for its ability to enter the cell nucleus directly and interact with signaling molecules involved in the inflammatory cascade.

• Molecular Simplicity: Its small size allows for high-resolution data in epithelial and intestinal cellular models where larger polypeptides may encounter transport limitations.

• Structural Stability: Lyophilized in a sterile, vacuum-sealed environment to maintain the integrity of the peptide bonds during baseline testing.

Laboratory Application Fields

1. NF-κB Pathway Research: Investigating the inhibition of nuclear translocation of NF-κB in various cellular stress models.

2. Epithelial Barrier Modeling: Analysis of the peptide’s influence on tight junction proteins and cellular wall integrity.

3. Cytokine Expression Studies: Evaluation of the suppression of IL-1, IL-6, and TNF-$\alpha$ in isolated biological samples.

4. Microbiome Interaction Research: Studying the antimicrobial properties and the modulation of the microenvironment in gut-on-a-chip models.

Storage & Handling Protocols

• Thermal Management: Store lyophilized vials at -20°C for long-term baseline preservation.

• Reconstitution: Rapidly soluble in 0.9% NaCl or sterile laboratory water. Once reconstituted, maintain at 2-8°C.

• Handling: KPV is a stable tripeptide, but it should still be protected from direct UV exposure and high-frequency agitation post-reconstitution.

IMPORTANT NOTICE & DISCLAIMER

FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.

Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.