Description
Product Name: Retatrutide Molecular Formula: C221H342N46O68 Molar Mass: ~4731.3 g/mol Sequence: Modified GIP backbone with specific amino acid substitutions and a C20 fatty diacid moiety.
Product Overview Retatrutide represents the next generation of incretin-based research. While Semaglutide is a mono-agonist (GLP-1) and Tirzepatide is a dual agonist (GLP-1/GIP), Retatrutide introduces a third component: Glucagon receptor agonism. Structurally, it is based on the GIP peptide backbone but is engineered with high potency at all three receptor sites. It includes a fatty acid side chain to prolong its half-life and enhance albumin binding.
Mechanism of Action Retatrutide leverages a triple-pathway approach to metabolic regulation:
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GIP Receptor Activation: Improves insulin sensitivity and potentiates insulin secretion, helping to regulate lipid storage and glucose uptake.
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GLP-1 Receptor Activation: Slows gastric emptying, induces satiety, and reduces food intake via central nervous system signaling.
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Glucagon (GCG) Receptor Activation: This is the distinguishing feature of Retatrutide. Glucagon agonism increases energy expenditure (thermogenesis) and promotes hepatic lipid clearance (breaking down liver fat), a mechanism absent in GLP-1/GIP dual agonists.
Research Applications Retatrutide is at the forefront of metabolic research, particularly for:
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Extreme Weight Loss: Investigating the “supra-maximal” weight reduction achievable through combined caloric restriction (GLP-1) and increased energy burn (Glucagon).
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NAFLD/NASH: Studying the rapid reduction of liver fat content and improvements in hepatic health markers, making it a key compound for non-alcoholic fatty liver disease research.
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Type 2 Diabetes: Assessing glycemic control through the complex interplay of insulin stimulation and glucose regulation.
Storage and Handling
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Storage: Store lyophilized powder at 2-8°C. Protect from light.
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Stability: Stable for 2 years when stored properly in lyophilized form. Reconstituted solutions should be kept at 4°C and used within a limited window to maintain structural integrity.
Disclaimer: This material is sold for research and development purposes only. It is not intended for human ingestion, diagnostic, therapeutic, or clinical procedures. All research must be conducted by qualified professionals in a laboratory setting.
