Description
Semax (5 mg)
Product Name: Semax
Molecular Formula:
Molar Mass: ~810.9 g/mol
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (ACTH 4-10 fragment)
Product Overview
Semax is a synthetic heptapeptide derived from a fragment of the adrenocorticotropic hormone (ACTH). Unlike the parent hormone, Semax possesses no hormonal activity but exhibits potent nootropic and neuroprotective properties. Developed in the 1980s-90s for the treatment of stroke and cognitive disorders, it has become a cornerstone in neurobiology research for its ability to cross the blood-brain barrier and modulate the central nervous system without the “crash” associated with traditional stimulants.
Mechanism of Action
Semax functions through several sophisticated neurochemical pathways:
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BDNF Upregulation: It significantly increases the expression of Brain-Derived Neurotrophic Factor (BDNF)and Nerve Growth Factor (NGF). These proteins are vital for the survival, development, and plasticity of neurons.
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Melanocortin System Modulation: It acts on melanocortin receptors, which influences inflammatory responses within the brain and helps regulate dopamine and serotonin levels
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Neuroprotection: It inhibits the breakdown of enkephalins (natural painkillers) and protects neurons from excitotoxicity and oxidative stress, particularly during periods of low oxygen (hypoxia).
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Gene Expression: Similar to GHK-Cu, Semax has been shown to rapidly shift the expression of genes related to the immune system and vascular health in brain tissue.
Research Applications
Semax is a primary subject in studies involving cognitive enhancement and recovery:
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Cognitive Enhancement: Researching improvements in focus, memory retention, and mental clarity during high-stress tasks or sleep deprivation.
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Neuro-Restoration: Studying its efficacy in recovering from traumatic brain injuries (TBI), strokes, and optic nerve damage.
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ADHD & Mood Research: Investigating its role in balancing neurotransmitters to improve attention span and mitigate symptoms of depression or anxiety.
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Ischemic Protection: Analyzing its ability to prevent neuronal death during ischemic events by improving the brain’s metabolic efficiency.
Storage and Handling
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Storage: Store lyophilized powder at 2-8°C for long-term stability.
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Stability: In its freeze-dried (lyophilized) state, Semax is stable for up to 2 years.
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Reconstitution: Once reconstituted with bacteriostatic water or saline, the solution is highly sensitive to temperature. It should be kept refrigerated at 4°C and used within 20–30 days to maintain maximum peptide integrity.
Disclaimer: This material is sold for research and development purposes only. It is not intended for human ingestion, diagnostic, therapeutic, or clinical procedures. All research must be conducted by qualified professionals in a laboratory setting.
