Sale!
SLU-PP-332 5 mg

SLU-PP-332 5 mg

Original price was: $40.00.Current price is: $33.00.

SLU-PP-332 (5 mg)
SLU-PP-332 is a synthetic research compound explored for its potential effects on cellular metabolism, mitochondrial efficiency, and energy regulation. Supplied as a 5 mg lyophilized powder, this material is intended strictly for laboratory research and in-vitro analysis.
For laboratory research use only. Not for human consumption.

In stock

Estimated delivery dates: Mar 4, 2026 - Mar 7, 2026
Category:

Description

Product Name: SLU-PP-332 Chemical Name: (E)-4-Hydroxy-N’-(naphthalen-2-ylmethylene)benzohydrazideMolecular Formula: C18H14N2O2 Molar Mass: ~290.32 g/mol Solubility: Soluble in DMSO (dimethyl sulfoxide)

Product Overview SLU-PP-332 is a novel, non-hormonal small molecule designed to activate the estrogen-related receptor (ERR) nuclear orphan receptors. Unlike estrogen receptors (ERs), ERRs do not bind natural estrogen but are critical regulators of cellular energy metabolism. SLU-PP-332 is distinct because it does not act as a traditional ligand but rather stabilizes the active conformation of the receptor, promoting the transcription of genes involved in energy expenditure.

Mechanism of Action SLU-PP-332 acts primarily through the activation of the ERR$alpha$/PGC-1$alpha$ signaling axis, a pathway central to metabolic regulation:

  1. Mitochondrial Biogenesis: It stimulates the creation of new mitochondria, increasing the cellular capacity for energy production.

  2. Fiber Type Switching: In murine models, it has been shown to induce a shift in skeletal muscle fibers towards Type IIa (oxidative) fibers, which are more fatigue-resistant.

  3. Fatty Acid Oxidation: The compound promotes the utilization of lipids for fuel, mimicking the metabolic state of fasting or endurance exercise.

  4. Lactate Clearance: Research suggests it may enhance the body’s ability to clear lactate, delaying muscle fatigue.

Research Applications SLU-PP-332 is a cutting-edge compound in metabolic and myology research, specifically for:

  • Obesity and Metabolic Syndrome: Investigating its ability to prevent diet-induced obesity and improve insulin sensitivity by increasing basal metabolic rate.

  • Sarcopenia and Muscle Wasting: Studying therapeutic avenues for conditions where exercise is not possible, such as atrophy due to aging or immobilization.

  • Cardiovascular Health: Exploring the role of ERR activation in maintaining cardiac function and preventing heart failure.

  • Endurance Performance: Assessing biochemical markers related to stamina and VO2 max improvement in animal models.

Storage and Handling

  • Storage: Store powder at 2-8°C. Protect from light and moisture.

  • Stability: Stable for 2 years in solid form. Solutions in DMSO should be prepared fresh or stored at -20°C for limited periods (up to 1 month).

Disclaimer: This material is sold for research and development purposes only. It is not intended for human ingestion, diagnostic, therapeutic, or clinical procedures. All research must be conducted by qualified professionals in a laboratory setting.

Related products