Description
Technical Monograph: T-SAM-10 | Stabilized GHRH Analog
Product Code: HRL-TES-10 | Total Peptide Mass: 10 mg
This high-purity synthetic 44-amino acid peptide is an analog of the endogenous Growth Hormone Releasing Hormone (GHRH). Engineered for advanced endocrine research, this 10 mg variant features a specialized 3-hexenoic acidmodification at the N-terminal, optimized for investigating the pulsatile secretion of growth hormone with superior enzymatic stability compared to native GHRH.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Sequence Base | Human GHRH (1-44) |
| Modification | N-Terminal (trans-3-hexenoyl) Group |
| Molecular Weight | 5135.9 g/mol |
| Purity (HPLC) | >99.0% |
| Total Mass | 10 mg Lyophilized Powder |
Analytical Characteristics
-
Enhanced Metabolic Stability: The N-terminal modification is specifically engineered to resist cleavage by dipeptidyl peptidase IV (DPP-IV), providing a longer observation window in plasma-simulated environments.
-
Somatotroph Selectivity: Formulated to study the activation of the GHRH-R on pituitary somatotrophs, leading to the synthesis and pulsatile release of endogenous growth hormone.
-
Lipolytic Pathway Research: Designed to investigate the reduction of ectopic fat and visceral adipose tissue markers in high-resolution metabolic cellular models.
Laboratory Application Fields
-
Pituitary Signaling Research: Investigating the dose-response relationship between GHRH analogs and pulsatile hormone secretion.
-
Visceral Adipose Tissue (VAT) Modeling: Analysis of the peptide’s influence on lipolysis and the regulation of lipid storage in deep-tissue adipocyte cultures.
-
IGF-1 Feedback Studies: Evaluation of the impact of sustained GHRH agonism on systemic insulin-like growth factor-1 (IGF-1) levels in vitro.
-
Cognitive Pathway Mapping: Studying the potential neuroprotective effects of GHRH-induced somatotropic activation in neural cell lines.
Storage & Handling Protocols
-
Thermal Management: Store lyophilized vials at -20°C for maximum molecular integrity.
-
Reconstitution: Maintain at 2-8°C post-reconstitution. Use sterile 0.9% NaCl or bacteriostatic laboratory water.
-
Stability: This 44-amino acid sequence is highly complex; avoid high-velocity agitation and protect from all UV exposure to prevent degradation of the N-terminal hexenoyl group.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
