Description
Product Name: META Blend (Custom Cellular Energy Stack) Components per Vial:
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NAD+ – 100 mg (Nicotinamide Adenine Dinucleotide)
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MOTS-c – 10 mg
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5-Amino-1MQ – 10 mg
Product Overview This formulation addresses metabolic efficiency from three distinct angles. While MOTS-c acts as a signal to increase mitochondrial biogenesis, 5-Amino-1MQ blocks the metabolic “sink” that wastes energy in fat cells. The addition of exogenous NAD+ ensures that the cellular pool of this critical coenzyme is maximally saturated. This blend is designed to create a “hyper-metabolic” state in research subjects, favoring energy expenditure over storage.
Mechanism of Action The META Blend operates through a reinforcing cycle of energy production and conservation:
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Direct Replenishment (NAD+): Provides a direct source of Nicotinamide Adenine Dinucleotide, the essential coenzyme required for ATP production and sirtuin (longevity gene) activation.
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Enzyme Inhibition (5-Amino-1MQ): Inhibits the enzyme NNMT. Normally, NNMT methylates nicotinamide, removing it from the NAD+ salvage pathway. By blocking this, 5-Amino-1MQ forces the cell to recycle nicotinamide back into NAD+, effectively “plugging the leak” in cellular energy.
- Mitochondrial Activation (MOTS-c): Activates the AMPK pathway, stimulating the cell to build more mitochondria and burn glucose/fatty acids for fuel. It provides the “machinery” to utilize the high energy levels created by the other two components.
Research Applications This complex blend is at the forefront of longevity and metabolic research, utilized to study:
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NAD+ Optimization: Investigating the synergistic effect of inhibiting NNMT while simultaneously supplementing NAD+.
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Obesity reversal: Targeting white adipose tissue to reduce fat mass and prevent the accumulation of new lipids.
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Sarcopenia & Frailty: Improving muscle function and recovery in aged models by restoring youthful mitochondrial density.
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Metabolic Syndrome: Assessing improvements in insulin sensitivity and lipid profiles.
Storage and Handling
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Storage: Store lyophilized powder at 2-8°C. Protect from light.
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Stability: Stable for 2 years in lyophilized form.
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Reconstitution Note: NAD+ is highly sensitive to degradation in solution. Once reconstituted, this blend must be kept at 4°C and used quickly (ideally within 1–2 weeks) to maintain the potency of the NAD+ component.
Disclaimer: This material is sold for research and development purposes only. It is not intended for human ingestion, diagnostic, therapeutic, or clinical procedures. All research must be conducted by qualified professionals in a laboratory setting.
