Description
Product Name: Semaglutide Molecular Formula: C187H291N45O59 Molar Mass: ~4113.58 g/mol Sequence: H-His-Aib-Glu-Gly-Th-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH
Product Overview Semaglutide is a modified synthetic analog of the incretin hormone glucagon-like peptide-1 (GLP-1).While native GLP-1 is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4), Semaglutide is engineered for resistance to DPP-4 inactivation. Its critical structural modification involves the acylation of the lysine residue at position 26 with a spacer and a C-18 fatty diacid chain. This allows for high-affinity binding to plasma albumin, facilitating a prolonged duration of action suitable for extended-release research protocols.
Mechanism of Action Semaglutide functions as a selective agonist for the GLP-1 receptor, a G-protein coupled receptor (GPCR) found in the pancreas, brain, and gastrointestinal tract. Upon receptor activation, research models observe:
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Glucose-Dependent Insulin Secretion: Enhancement of insulin synthesis and release from pancreatic beta cells specifically under elevated glucose conditions.
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Glucagon Suppression: Inhibition of inappropriate glucagon secretion from alpha cells, reducing hepatic glucose output.
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Gastric Emptying: A marked deceleration of gastric emptying rates, which influences nutrient absorption kinetics.
Research Applications Semaglutide is a benchmark compound in metabolic research, frequently employed in studies regarding:
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Type 2 Diabetes: Investigating mechanisms of glycemic control and beta-cell preservation.
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Weight Management: Studying the central nervous system (CNS) pathways involved in satiety, food intake regulation, and body weight reduction.
- Cardiovascular Health: assessing the impact of GLP-1 agonism on cardiovascular risk markers and endothelial function.
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Neuroprotection: Emerging research into the potential neuroprotective effects of GLP-1 analogs in models of neurodegenerative disorders.
Storage and Handling
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Storage: Store lyophilized powder at 2-8°C. Reconstituted solutions should be kept at 4°C and used within a limited timeframe.
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Stability: Stable for 2 years when stored properly in lyophilized form. Avoid repeated freeze-thaw cycles.
Disclaimer: This material is sold for research and development purposes only. It is not intended for human ingestion, diagnostic, therapeutic, or clinical procedures. All research must be conducted by qualified professionals in a laboratory setting.
